The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
FROM TEEN IDOL TO TIMELESS: SEE HOW THIS ’90S STAR ROCKS GRAY HAIR AT 61
In the ’90s, many heartthrobs won the hearts of millions, and one actor from that era still captures attention today.
Now 61 years old, he has embraced his natural look, including his gray hair, and continues to charm fans with his signature crystal-blue eyes.
Born on July 22, 1963, in Norfolk, Virginia, this actor became famous through popular TV shows like “Silk Stalkings,” “Melrose Place,” and “90210.” His talent and good looks made him a star, and his unique blue eyes made him even more memorable.
Fans often rave about his Instagram posts, where his natural aging look, including his gray hair, has earned comments like “Aging like fine wine” and “Still a hot man! A year older than me and looking great.”
Many people appreciate how he stays true to himself. One fan wrote, “You look amazing! Naturally youthful. You are living well, congrats!” Another fan reminisced, saying, “My teenage crush.”
His eyes have always been a standout feature, and fans have never forgotten them. Even though time has brought silver streaks to his hair, his captivating eyes—still bright and clear—continue to be a major point of admiration.
Fans often comment on his eyes, with one saying, “Oh, those beautiful eyes of yours,” and another noting, “Your eyes are literally crystals.” One fan summed it up with, “One of my favorite male actors. He keeps getting better looking as he ages.”
His choice to age naturally, without cosmetic treatments, sets him apart in an industry often fixated on youth. This decision has strengthened his bond with fans, who see him as not just a past heartthrob but as a symbol of authenticity and self-acceptance.
It’s always inspiring to see someone embrace their journey and stay true to themselves. If there’s anything specific you’d like to explore or any other topic you’re interested in, just let me know!
Rob Este’s choice to marry Erin Bolte and their move to San Clemente reflect his commitment to a stable and family-focused life. It’s wonderful how he’s managed to balance his public career with a fulfilling personal life. If you want to dive into more details about their life or anything else, just let me know!
Rob Este and Erin Bolte’s move to San Clemente provided the perfect backdrop for their family life. The peaceful beachside town was ideal for raising their children. Rob’s older kids, Mason and Maya, from his previous marriage to Josie Bissett, also enjoyed the new environment. It sounds like a great setting for their family life!
Rob Este and Erin Bolte’s move to San Clemente marked a new chapter in their lives. While Mason, Rob’s son from his previous marriage, lived with them and went to San Clemente High School, Maya, his daughter, stayed in Seattle with her mother but visited often.
Rob and his ex-wife, Josie Bissett, have a good co-parenting relationship, which helps their kids feel supported by both parents.
Their new home is a four-bedroom house by the beach, a big upgrade from their old, smaller place in Santa Monica. The beachside location, which they call their “bubble,” is perfect for their family-oriented lifestyle.
San Clemente is also special for Erin and Rob because it’s where they first met on a blind date set up by friends. At that time, Rob was living between Seattle and Los Angeles and stayed with his sister in San Clemente. He later found a role in “The Women’s Murder Club” and moved to Santa Monica.
Despite his busy career, Rob makes sure to be home for family dinners almost every night, showing how important family values are to him.
The Bolte-Estes family values their time together, and their “no electronics at dinner” rule is a key part of their routine. This rule helps them connect with each other and enjoy their meals without distractions. Erin and Rob’s approach to family life reflects their commitment to simplicity and togetherness, making their home in San Clemente a special place for shared moments and meaningful connections.
Rob Estes, now 61, has embraced a peaceful life in San Clemente with his wife, Erin, and their blended family. Despite the pressures of fame, he finds joy and relaxation in music and gardening. Playing music has been a passion since his school days, and gardening helps him unwind, especially when he’s stressed.
Erin jokes that when Rob isn’t happy, the trees in their garden seem to go away, but in reality, he channels his energy into maintaining their garden, which brings him calm and fulfillment.
Though he has stepped back from the spotlight, Estes continues to act in roles that are meaningful to him. In December 2023, fans were excited to see him in the trailer for the movie “Beautiful Wedding,” showing that his love for acting is still strong.
Living in San Clemente, Estes has redefined success by focusing on family and a slower pace of life. His commitment to a simpler, more personal life demonstrates that true success comes from the quality of one’s personal life, not just fame.
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