The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
Elvis Presley’s Grandson Takes the Stage and Shows His Talent
In a riveting display of talent on “The Voice”, Dakota Striplin made a bold claim that sent shockwaves through the competition: he hinted at being the descendant of the legendary Elvis Presley. Commanding the stage with charisma and skill, Dakota enraptured both judges and audience alike with a rendition of “Love Me Tender” that echoed the spirit of the King himself. Armed only with his guitar, he delivered a performance that was both haunting and electrifying.
The first judge, visibly moved by Dakota’s ethereal vocals, swiveled her chair in a gesture of admiration, her hand resting over her heart. It didn’t take long for another judge to follow suit, drawn in by Dakota’s magnetic presence and undeniable talent, eager to unravel the mystery behind this mesmerizing performance.
Following his spellbinding act, the judges couldn’t help but inquire about Dakota’s choice of song and the inspiration behind it. With heartfelt sincerity, Dakota shared anecdotes of his family’s connection to Elvis, recounting his grandmother’s fond memories of attending the King’s concerts. He even injected a bit of humor into the conversation, playfully hinting at a familial resemblance to the rock and roll icon that left the judges chuckling.
But Dakota didn’t stop there, he tantalized the panel with hints of other intriguing facets of his lineage, alluding to a recent DNA revelation that cast doubt on his established ancestry and hinted at a potential link to Elvis Presley himself.
Embark on a journey through Dakota Striplin’s captivating performance and enigmatic backstory by tuning in to the full video below.
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