Although numerous renowned friendships appear enduring, the truth remains that even the strongest connections can deteriorate amidst the strains of fame, rivalry, or divergent personal paths. Below are 10 celebrity duos who were formerly inseparable but have since ceased communication.
Lindsay Lohan and Paris Hilton
Lindsay Lohan and Paris Hilton were once party pals, frequently spotted together at Hollywood hotspots. However, their friendship soured with rumors of betrayal and rivalry, with Lindsay reportedly dating Paris’s ex-boyfriend. Their feud escalated with public insults, leading to a complete breakdown of their relationship. Recently, Paris Hilton shared that she congratulated Lohan on her wedding, but their friendship might not ever be the same again.
Taylor Swift and Katy Perry
The well-known feud between Taylor and Katy has been widely publicized. Formerly on good terms, their relationship turned sour, with both airing grievances through hit songs. Katy allegedly poached Taylor’s backup dancers, leading to Taylor’s «Bad Blood» track. Katy addressed the conflict on The Late Show With James Corden, expressing her attempts to resolve it but receiving no response from Taylor. She emphasized the concept of karma and cause and effect in their feud.
Selena Gomez and Demi Lovato
Selena Gomez and Demi Lovato were once Disney darlings and best friends, supporting each other through thick and thin. However, their friendship ended due to personal problems, made worse by Demi’s struggles with mental health. Despite attempts at reconciliation, their relationship remains strained.
Mariah Carey and Jennifer Lopez
Jennifer Lopez and Mariah Carey were once friendly acquaintances in the music industry. However, their feud played out publicly, with both artists making subtle digs at each other in interviews and through their music. Despite occasional attempts to downplay their feud, their strained relationship remains apparent.
Beyoncé and Kim Kardashian
Beyoncé and Kim Kardashian’s relationship was initially friendly. However, their friendship reportedly cooled when Beyoncé and Jay-Z didn’t attend Kim and Kanye West’s wedding. Different lifestyles might be the reason why they fell out.
Paris Hilton and Nicole Richie
Paris Hilton and Nicole Richie rose to fame together as the stars of The Simple Life. However, their friendship fizzled out between rumors of betrayal and personal differences. Their rift played out publicly, with both parties mocking each other in the media. Recently, Nicole stated that she still thinks Paris is her friend.
Drake Bell and Josh Peck
Nearly everyone who’s sported Mickey Mouse ears was devastated upon learning about the rift between Drake Bell and Josh Peck. While Peck exchanged vows with his fiancé, Bell found himself absent from the guest list, prompting him to take to Twitter to express his feelings about his perceived snub.
«When you’re not invited to the wedding, the message is clear,» Bell lamented in a series of now-deleted tweets. «True colors have come out today. Message is loud and clear. Ties are officially cut. I’ll miss you brotha,» he continued. «Loyalty is key.» «ALWAYS remember where you came from.» Later, Bell admitted to Entertainment Tonight that he regretted his Twitter outburst and acknowledged that he should have directly addressed the issue with Josh.
Within the realm of celebrities, friendships often prove as fragile as they are fleeting. Though these stars may have once reveled in laughter and shared good times, their bonds eventually faltered. Despite the public scrutiny surrounding their rifts, some cling to hope for reconciliation, while others have come to terms with the fact that their friendships belong solely to the annals of the past.
We’ve All Waited for It: Scientists Created a Drug That Can Help Regrow Lost Teeth
The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
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